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Titlebook: Circadian Pharmacokinetics; Baojian Wu,Danyi Lu,Dong Dong Book 2020 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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樓主
發(fā)表于 2025-3-21 19:25:07 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Circadian Pharmacokinetics
編輯Baojian Wu,Danyi Lu,Dong Dong
視頻videohttp://file.papertrans.cn/227/226571/226571.mp4
概述Reinforces basic knowledge and principles on circadian clock and metabolic diseases.Enriches understanding of circadian regulation of drug metabolism and transport.Serves as a helpful reference and pr
圖書封面Titlebook: Circadian Pharmacokinetics;  Baojian Wu,Danyi Lu,Dong Dong Book 2020 The Editor(s) (if applicable) and The Author(s), under exclusive licen
描述This book summarizes the recent advances for the understanding of circadian clock system in the regulation of drug metabolism and pharmacokinetics. Basic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book‘s contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.
出版日期Book 2020
關(guān)鍵詞Pharmacokinetics; Circadian clock; Drug-metabolizing enzymes; Uptake and efflux transporters; Chronother
版次1
doihttps://doi.org/10.1007/978-981-15-8807-5
isbn_softcover978-981-15-8809-9
isbn_ebook978-981-15-8807-5
copyrightThe Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapor
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-22 00:06:59 | 只看該作者
板凳
發(fā)表于 2025-3-22 02:56:06 | 只看該作者
ers are summarized, and the underlying mechanisms thereof (i.e., regulation by circadian oscillators) are discussed. Typically, evidence for the DME- and transporter-mediated chronopharmacokinetics, chronotoxicity and chronoefficacy are highlighted in this book.978-981-15-8809-9978-981-15-8807-5
地板
發(fā)表于 2025-3-22 08:17:41 | 只看該作者
5#
發(fā)表于 2025-3-22 10:48:12 | 只看該作者
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發(fā)表于 2025-3-22 13:26:13 | 只看該作者
Lay James Gibson,James B. Nelsondependent drug pharmacokinetics and therapeutic outcomes. In this chapter, we update current knowledge on uptake transporters that contribute significantly to drug transport and pharmacokinetics. Particularly, regulation of uptake transporters by circadian clock and the underlying mechanisms are covered.
7#
發(fā)表于 2025-3-22 17:10:22 | 只看該作者
Tatsuhiko Kawashima,Iwan Azis,Michael Taned with dosing time-dependency in pharmacokinetics and drug effects. In this chapter, we review circadian regulation of efflux transporters and its influences on drug disposition, toxicity, and efficacy.
8#
發(fā)表于 2025-3-22 21:16:36 | 只看該作者
Tatsuhiko Kawashima,Iwan Azis,Michael Tane-dependent drug effects is highly relevant for chronotherapeutics. In this chapter, we perform a review on the influences of circadian rhythms on drug pharmacokinetics in both humans and experimental animals. We also discuss the role of pharmacokinetics in chronotherapeutics.
9#
發(fā)表于 2025-3-23 01:40:15 | 只看該作者
Introduction to Mammalian Circadian Clock System,iseases present circadian rhythms in flares of symptoms. Thus, it is of great interest to investigate circadian rhythms in depth, which would help to find means to combat diseases and to optimize drug treatment. In this chapter, we introduce mammalian circadian clock system and discuss the role of circadian clock in human health.
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發(fā)表于 2025-3-23 08:16:25 | 只看該作者
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