Titlebook: Circadian Pharmacokinetics; Baojian Wu,Danyi Lu,Dong Dong Book 2020 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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佛刊

Role of Non-Pharmacokinetic Factors in Chronoefficacy,s and minimize adverse effects. Circadian factors contributing to time-varying drug effects can be divided into pharmacokinetic and non-pharmacokinetic factors. Main non-pharmacokinetic factors include drug target and disease severity (flares of symptoms) that vary according to time of the day. Ther

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https://doi.org/10.1007/978-981-15-8807-5Pharmacokinetics; Circadian clock; Drug-metabolizing enzymes; Uptake and efflux transporters; Chronother

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Exposition

Ali Alsamawi,Oliver Fritz,Norihiko Yamanoound its own axis. All forms of life have evolved biological clocks to adapt (and to synchronize) their physiology and behaviors to circadian environmental changes. This adaptation results in circadian rhythms (with a period of ~24?h) in many physiological and behavioral processes such as the sleep–

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Ali Alsamawi,Oliver Fritz,Norihiko Yamano drug exposure in the body and therefore pharmacological effects. In general, drug molecules undergo four main disposition processes in the body, namely absorption, distribution, metabolism, and excretion (ADME, the so-called four components of pharmacokinetics). Pharmacokinetic study is an integral