Titlebook: Circadian Pharmacokinetics; Baojian Wu,Danyi Lu,Dong Dong Book 2020 The Editor(s) (if applicable) and The Author(s), under exclusive licen

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https://doi.org/10.1007/978-3-030-61274-0. Circadian clock is known to impact drug efficacy and toxicity through regulating metabolism and pharmacokinetics. Ongoing research has begun to unveil the molecular mechanisms by which clock genes regulate circadian CYP expression and chronopharmacokinetics. On the other hand, CYP activities affec

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Martin Schneider,Manfred M. Fischerlock on non-CYP phase I metabolism are highlighted recently in mice lacking the clock gene ., . or .. .-deficient mice show altered expression of non-CYP phase I enzymes and blunted rhythms in enzyme expression. In addition, circadian expressions of non-CYP phase I enzymes (e.g., FMO5) are associate

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