Titlebook: Circadian Pharmacokinetics; Baojian Wu,Danyi Lu,Dong Dong Book 2020 The Editor(s) (if applicable) and The Author(s), under exclusive licen

英寸

Circadian Clock and Uptake Transporters,dependent drug pharmacokinetics and therapeutic outcomes. In this chapter, we update current knowledge on uptake transporters that contribute significantly to drug transport and pharmacokinetics. Particularly, regulation of uptake transporters by circadian clock and the underlying mechanisms are covered.

低三下四之人

adduction

Role of Pharmacokinetics in Chronotherapeutics,-dependent drug effects is highly relevant for chronotherapeutics. In this chapter, we perform a review on the influences of circadian rhythms on drug pharmacokinetics in both humans and experimental animals. We also discuss the role of pharmacokinetics in chronotherapeutics.

冰雹

Book 2020sic knowledge in the field of circadian clock and pharmacokinetics are systemically introduced to make it easier for readers to understand the entire book‘s contents. The rhythmic expression of DMEs (drug-metabolizing enzymes) and transporters are summarized, and the underlying mechanisms thereof (i

Mawkish

KEGEL

Martin Schneider,Manfred M. Fischerregimen optimization to maximize efficacy and reduce toxicity. In this chapter, we review non-CYP phase I enzymes whose expression and activity vary with time of the day. We also discuss the molecular mechanisms underlying circadian expression of non-CYP phase I enzymes.

法官

浮雕

權(quán)宜之計

傻瓜

Circadian Clock and Non-CYP Phase I Metabolism,regimen optimization to maximize efficacy and reduce toxicity. In this chapter, we review non-CYP phase I enzymes whose expression and activity vary with time of the day. We also discuss the molecular mechanisms underlying circadian expression of non-CYP phase I enzymes.