Titlebook: Manual of Biological Markers of Disease; W. J. Venrooij,R. N. Maini Book 1996 Springer Science+Business Media Dordrecht 1996 Antigen.Labor

主動(dòng)脈

Immunoprecipitation of labelled proteinsre components of subcellular particles (for review see [1]). These subcellular particles frequently comprise aggregates of several different proteins, with or without different species of RNA. Specific immunoprecipitation using a defined autoantibody, therefore results in the precipitation of not on

Osteoarthritis

Analysis of autoimmune sera by immunoprecipitation of cellular RNPss of cytoplasmic and nuclear ribonucleoprotein (RNP) particles (reviewed in [1]). Patients with systemic lupus erythematosus (SLE), mixed connective tissue disease (MCTD) and Sj?gren’s syndrome often develop antibodies against the snRNP, Ro and La ribonucleoprotein particles, respectively (Table 1).

使隔離

Measurement of antibodies to DNAs disease, which makes their detection an important diagnostic aid to the clinician. Fluctuations in the level of anti-dsDNA in an individual patient generally parallel the clinical status of that patient. Furthermore, the presence of anti-dsDNA may precede the diagnosis of SLE by more than a year.

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legislate

DNA as antigen in SLEr single-stranded (ssDNA); the influence of DNA strands will be further discussed in paragraph 14. Furthermore, DNA as antigen will . almost always occur in the form of nucleosomes, i.e. closely associated with histones.

四目在模仿

mechanical

Scleroderma-associated antigensrologic markers have been shown to be useful in diagnosis and identifying disease subsets [3–5]. A number of autoantigens in scleroderma have been described. The most important are: DNA topoisomerase I (110 kDa) [3, see also this Manual, chapter B-5.1], the centromere proteins CENP-A (17 kDa), CENP-