Titlebook: Eicosanoids and Other Bioactive Lipids in Cancer and Radiation Injury; Proceedings of the 1 Kenneth V. Honn,Lawrence J. Marnett,Thomas L. W

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8-Hydroxydeoxyguanosine, a DNA Adduct Formed by Oxygen Radicals: Its Implications on the Mutagenic adeoxyguanosine residues in DNA is hydroxylated to produce 8-hydroxydeoxyguanosine (8-OH-dG) in DNA . by various oxygen radical-producing agents (3). The formation of 8-OH-dG was also observed in cellular DNA when mice or rats were irradiated by ionizing radiation or administrated oxygen radical-forming carcinogens (4–6).

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Radiation Protection and Cancer Therapy by Linoleately, therefore, that combined radiation and LA therapy may be useful for the control of selected cancers. We have begun an investigation of the combined therapy both by clinical studies of the safety and efficacy of LA therapy in 41 dogs and 12 cats with advanced cancer and by laboratory studies.

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