Titlebook: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays; Franz J. Hock,Michael K. Pugsley Reference work 2024Latest edition Sprin

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Blood Constituents and Safety Pharmacology: In Vitro and In Vivo Thrombosis and Hemostasis Assaysromboembolism, acute coronary syndromes, cerebral vascular ischemic and thrombotic events, and diseases associated with thrombotic disorders has provided additional insights toward the development of various therapeutic approaches to control these pathogenic events. The roles of plasmatic proteins,

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Current Assays in Endocrine Safety Pharmacologylated findings in repeated-dose toxicity studies. Such findings may be changes in organ weight and/or histopathology, abnormal findings in biochemistry, and/or endocrine biomarkers. They are needed to detect undesirable pharmacodynamic effects of a substance on endocrine system in relation to exposu

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Skin Pharmacologyrial chemicals, and pesticides. In this chapter, we will discuss the rationale, procedure, accuracy, safety, advantages, and disadvantages of these assays when experimented with in vitro and in vivo, both in animals (mice, guinea pigs, …) and humans..The Organisation for Economic Co-operation and De

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Liver Systems in Safety Pharmacologyk chapter delves into various aspects of liver function, metabolism, and toxicity assessment in the context of drug development. Beginning with an overview of the liver’s role in drug metabolism and its importance in ensuring drug safety, the discussion progresses to explore the intricacies of liver

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Peripheral Nervous SystemExp Pathol Pharmakol 93:72–91, 1922; Schaumann, Naunyn-Schmiedeberg’s Arch Exp Pathol Pharmakol 190:30–51, 1938; Camougis and Takman, Nerve and nerve-muscle preparations (as applied to local anesthetics). In: Schwartz A (ed) Methods in pharmacology, vol 1. Appleton-Century-Crofts. Educational Divisi

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