Titlebook: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays; Franz J. Hock,Michael K. Pugsley Reference work 2024Latest edition Sprin

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Computational Cardiac Safety Testingtainty, how to assess simulation reliability and reproducibility, and therefore how to establish trust in model predictions. We examine applications of simulations to date, particularly in the context of the comprehensive in vitro proarrhythmia Assay (CiPA). The chapter concludes with a discussion of future avenues for research.

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The adverse effects of new chemical entities (NCE) in animals and humans can manifest as changes in the structural, biochemical, or physiological status of the organism (see Fig. .). In the preclinical safety assessment process, toxicological procedures have traditionally focused on the structural and biochemical consequences of drug actions.

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Safety Pharmacology: IntroductionThe adverse effects of new chemical entities (NCE) in animals and humans can manifest as changes in the structural, biochemical, or physiological status of the organism (see Fig. .). In the preclinical safety assessment process, toxicological procedures have traditionally focused on the structural and biochemical consequences of drug actions.