Titlebook: Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays; Franz J. Hock,Michael K. Pugsley Reference work 2024Latest edition Sprin

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Renal System in Safety Pharmacologyf functional nephron mass ((Newman DJ, Price CP. Tietz textbook of clinical chemistry. WB Saunders, Philadelphia, 1999)1999). Thus, assessment of the plasma level of such a constituent can serve as a biomarker of renal function, and several have been used extensively for this purpose.

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Peripheral Nervous Systemmuscle preparations (as applied to local anesthetics). In: Schwartz A (ed) Methods in pharmacology, vol 1. Appleton-Century-Crofts. Educational Division, Meredith Corp, New York, pp 1–40, 1971). Special local tolerance tests have been developed for each of these applications including peridural and intrathecal injections.

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https://doi.org/10.1007/978-3-642-61426-2re in the therapeutic range and above. The main objective is to decide whether the test compound can be administered to humans, which effects need to be monitored in clinical pharmacology and which clinical investigations are required for the risk evaluation.

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ent and decision making.Of use for government institutions a.Many aspects of drug safety have become an outstanding and even persistent issue and may occur during the process of both drug discovery and development. Until 15 years ago, drug discovery and evaluation was primarily a sequential process

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