Titlebook: Drug-Induced Liver Toxicity; Minjun Chen,Yvonne Will Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Acute li

Nonconformist

Service Integration in Supported Employmentcytes. Multiple hepatocyte derived cellular carcinoma cell lines, such as HepG2, Huh7, and HepaRG cells, have been established over the years, and they display distinct characteristics regarding the expression and activity levels of drug-metabolizing enzymes and other hepatocyte-specific factors. Th

Dignant

oblique

Danica Damljanovi?,Kalina Bontchevaon reasons given for drug attrition or withdrawal; this occurs for a multitude of reasons among which is certainly the lack of adequate models able to recapitulate hepatotoxicity in vitro. The loss of compounds in late-stage testing or after marketing is a major financial burden for the pharmaceutic

薄荷醇

脆弱吧

箴言

HATCH

Adaptive Reactive Rich Internet Applicationscombines automated imaging with image analysis to assess cell health and customized parameters in a multiparametric fashion, enabling coverage over several mechanisms important for DILI. In simple two-dimensional cell models, various HCS assays typically show a sensitivity of ~50% with a high specif

Incompetent

https://doi.org/10.1007/978-1-4939-7677-5Acute liver failure; Drug development; Regulatory processes; Preclinical and clinical studies; Hepatotox

Cumulus

Flavouring

Background Agents and Local Notifications,phases of drug development. Considerable efforts are dedicated to the detection and understanding of idiosyncratic DILI, and to the prediction of intrinsic DILI. Ever more complex and biologically relevant in vitro models are emerging for compound prescreening purposes. These data are also being use