Titlebook: Drug-Induced Liver Toxicity; Minjun Chen,Yvonne Will Book 2018 Springer Science+Business Media, LLC, part of Springer Nature 2018 Acute li

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書目名稱Drug-Induced Liver Toxicity影響因子(影響力)




書目名稱Drug-Induced Liver Toxicity影響因子(影響力)學(xué)科排名




書目名稱Drug-Induced Liver Toxicity網(wǎng)絡(luò)公開度




書目名稱Drug-Induced Liver Toxicity網(wǎng)絡(luò)公開度學(xué)科排名




書目名稱Drug-Induced Liver Toxicity被引頻次




書目名稱Drug-Induced Liver Toxicity被引頻次學(xué)科排名




書目名稱Drug-Induced Liver Toxicity年度引用




書目名稱Drug-Induced Liver Toxicity年度引用學(xué)科排名




書目名稱Drug-Induced Liver Toxicity讀者反饋




書目名稱Drug-Induced Liver Toxicity讀者反饋學(xué)科排名

機構(gòu)

Detection, Elimination, Mitigation, and Prediction of Drug-Induced Liver Injury in Drug Discovery major hurdle and is recognized to be a major cause of drug attrition and market withdrawal. DILI impacts many different sectors of society including patients, public health systems, health insurers and the pharmaceutical industry. Animal models are very efficient at detecting direct, dose-dependent

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方舟

Physicochemical Properties and Structural Alertsm the market. Significant efforts are being made to utilize existing knowledge of chemical and biological mechanisms that have been linked with causing DILI. These mechanisms are often varied and can include overt chemical reactivity or bioactivation to reactive metabolites; unintended interactions

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別名

Prediction of Human Liver Toxicity Using In Vitro Assays: Limitations and Opportunitiess. Simple single cell-type in vitro cytotoxicity assays may fail to predict complex in vivo interconnected mechanism-based toxicities. Additionally, the lack of standardization of in vitro assays complicates data interpretation and makes assay comparison difficult. The selection of a given assay may

APNEA

Use of Liver-Derived Cell Lines for the Study of Drug-Induced Liver Injurycytes. Multiple hepatocyte derived cellular carcinoma cell lines, such as HepG2, Huh7, and HepaRG cells, have been established over the years, and they display distinct characteristics regarding the expression and activity levels of drug-metabolizing enzymes and other hepatocyte-specific factors. Th

提煉

Evaluation of Drug-Induced Liver Injuries (DILI) with Human Hepatocytes: Scientific Rationale and Ex. Here the Human Cell Paradigm, namely, that human-specific drug properties can be obtained with in vitro human-based experimental systems is proposed. The success of the Human Cell Paradigm depends on the physiological relevance of the in vitro system, namely, the retention of human-specific and or

MUT

Status and Use of Induced Pluripotent Stem Cells (iPSCs) in Toxicity Testingon reasons given for drug attrition or withdrawal; this occurs for a multitude of reasons among which is certainly the lack of adequate models able to recapitulate hepatotoxicity in vitro. The loss of compounds in late-stage testing or after marketing is a major financial burden for the pharmaceutic