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Titlebook: Cortical Deficits in Schizophrenia; From Genes to Functi Patricio O‘Donnell Book 2008 Springer-Verlag US 2008 DNA.Motivation.attention.beha

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發(fā)表于 2025-3-21 17:33:33 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Cortical Deficits in Schizophrenia
副標(biāo)題From Genes to Functi
編輯Patricio O‘Donnell
視頻videohttp://file.papertrans.cn/239/238842/238842.mp4
概述Presents the latest research on how genetic predisposition can produce schizophrenia’s pathophysiological outcomes
圖書封面Titlebook: Cortical Deficits in Schizophrenia; From Genes to Functi Patricio O‘Donnell Book 2008 Springer-Verlag US 2008 DNA.Motivation.attention.beha
描述The genetics of schizophrenia have taken the driver seat in the research - lated to this disorder in recent years. For a long time, it had been known that sharing genes with someone affected with schizophrenia conferred a 50% chance of acquiring the disease. Although this is fifty times the incidence in the normal population, it was evident that genes could not explain all factors involved. At best, one could think of a combination of gene traits conferring predisposition for the disease. Now, it is evident that although there are no genes that individually confer a strong liability, several candidate gene alleles do confer some risk, and perhaps a combination of genes could cause the emergence of symptoms in this multi-faceted psychiatric condition. As the research on predisposing genes soars, it is becoming clear that we need to be able to identify cellular processes the genes control and to provide pat- physiological scenarios that could link those cellular phenomena with sy- toms. In this book, we have chosen to elaborate on that link. The contributions to this book have been requested to reflect the current state of the connection between schizophrenia genetics and pathophysio
出版日期Book 2008
關(guān)鍵詞DNA; Motivation; attention; behavior; genes; genetics; physiology; schizophrenia
版次1
doihttps://doi.org/10.1007/978-0-387-74351-6
isbn_softcover978-1-4899-9304-5
isbn_ebook978-0-387-74351-6
copyrightSpringer-Verlag US 2008
The information of publication is updating

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Towards a Molecular Classification of Illness: Effects of Schizophrenia Susceptibility Loci on Clintion (or positive symptoms), apathy, avolition, and asociality (or negative symptoms), and cognitive impairment. No single symptom, or symptom cluster, is pathognomonic, and the current classification of the disorder into the Diagnostic and Statistical Manual IV (DSM-IV) (First et al. 1997) subtypes
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Homer: A Genetic Factor in Schizophrenia?,ological, brain imaging, pharmacological, genetic and biochemical research in affected individuals, as well as behavioral, molecular and neurochemical data derived from preclinical animal models of schizophrenia and related disorders (e.g., drug-induced psychosis) (Coyle 2006; Coyle and Tsai 2004; K
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Cortical Circuit Dysfunction in the NMDA Receptor Hypofunction Model for the Psychosis of Schizophris nonetheless an extremely subtle dysfunction that has proven remarkably difficult to define. The most widely recognized cognitive deficit associated with schizophrenia is a working memory abnormality. Cognitive deficits assessed by the more traditional neuropsychological tests, including the Wisco
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Identifying Novel Target Genes in Psychotic Disorder Network Association Analyses,o explore this idea, gene expression profiling (GEP) studies of “whole” hippocampus (HIPP) have been performed on a cohort consisting of SZs, BDs and normal controls and the data have been interrogated using a combination of a global functional analysis of biopathways/clusters and network associatio
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Alterations in Cortical GABA Neurotransmission in Schizophrenia: Causes and Consequences,nt to which this heterogeneity reflects variability (variance of a particular parameter within a class) and diversity (the existence of different classes within a population) remains to be determined. As demonstrated by the other volumes in this book, multiple molecular, cellular and circuitry candi
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