Titlebook: Cancer Biology and the Nuclear Envelope; Recent Advances May Eric C. Schirmer,Jose I. de las Heras Book 2014 The Editor(s) (if applicable)

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Book 2014understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE? is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA traff

LUCY

Contributions to Psychology and Medicineery important functional hub for many cellular processes. In this review we give an overview of the links between cancer biology and nuclear envelope, from the early days of microscopy until the present day’s understanding of some of the molecular mechanisms behind those links.

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https://doi.org/10.1007/978-3-662-08957-6ith several important signal transduction pathways. Here we describe the current state of knowledge and speculate that lamins may be intimately involved in the regulation of cell proliferation, acting at the interface between cancer and aging.

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Zerebrale Blindheit und Gesichtsfeldausf?lleM populations, sometimes associated with the induction of senescence. Intriguingly, most of the NETs linked to the cell cycle are highly restricted in their tissue expression; thus, their misregulation in cancer could contribute to the many tissue-specific types of cancer.

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NETs and Cell Cycle RegulationM populations, sometimes associated with the induction of senescence. Intriguingly, most of the NETs linked to the cell cycle are highly restricted in their tissue expression; thus, their misregulation in cancer could contribute to the many tissue-specific types of cancer.

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Studying Lamins in Invertebrate Modelsomote such studies. Here we provide an overview of recent advances in the biology of invertebrate nuclear lamins, with special emphasis on their assembly, cellular functions and as models for studying the molecular basis underlying the pathology of human heritable diseases caused by mutations in lamins A/C.

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