Titlebook: Cancer Biology and the Nuclear Envelope; Recent Advances May Eric C. Schirmer,Jose I. de las Heras Book 2014 The Editor(s) (if applicable)

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Roles of the Nucleoporin Tpr in Cancer and Agingscription, and mitosis. More recently, Tpr function has been linked to events including p53 signaling and premature aging in Hutchinson–Gilford Progeria Syndrome (HGPS). Here we provide an overview of the various processes that involve Tpr, and discuss how the levels and localization of a single protein can affect diverse pathways in the cell.

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0065-2598 ot topic, juxtaposing some of the historical and contemporar."Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE im

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Diabetes and Adaptations in Family Systemsthe clonal evolution of genetically unstable tumors. Two examples of this group include increased ratio of nuclear volume to cytoplasmic volume and the relatively fragile nuclei of small-cell carcinomas. The third and most interesting group develops in a near-diploid, genetically stable background.

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Heinrich H. Bülthoff,Alexa I. Ruppertsberg tissue sections by employing immunoperoxidase staining for emerin. Direct detection of nuclear envelope irregularities by tagging nuclear membrane proteins such as lamin B and emerin has resulted in a more objective definition of the shape of the nucleus. In this review we discuss in detail methodo

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Neuronale Grundlagen der Merkmalsintegrationuclear periphery, and sequester transcription factors away from the nuclear interior. On the other hand, proteins of the nuclear pores anchor as well as help generate active chromatin, promote transcription, and coordinate gene expression with mRNA export. The importance of these functions is unders

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Visuelle Wahrnehmung: Was, Wo und Wie,nvelope defects can restore proper gene positioning and expression in both disease situations..Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply