Titlebook: Cancer Biology and the Nuclear Envelope; Recent Advances May Eric C. Schirmer,Jose I. de las Heras Book 2014 The Editor(s) (if applicable)

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Paul Hoff,Anastasia Theodoridoum or nucleoplasm while others are incorporated into the NPC, and in all these cases they are thought to misregulate signaling pathways and transcription through either altered or diminished nucleoporin functionality. Intriguingly, many viruses target the same cancer-linked nucleoporins, often causin

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The Role of the Nuclear Lamina in Cancer and Apoptosisrentiation and the appearance of A-type lamins in a tumor likely relates the proliferative capacity of the tumor to its differentiation state..While lamins are targets for degradation in the apoptotic process, and accordingly are often used as markers for apoptosis, intriguing studies on an active r

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The Diagnostic Pathology of the Nuclear Envelope in Human Cancersthe clonal evolution of genetically unstable tumors. Two examples of this group include increased ratio of nuclear volume to cytoplasmic volume and the relatively fragile nuclei of small-cell carcinomas. The third and most interesting group develops in a near-diploid, genetically stable background.

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Nuclear Morphometry, Epigenetic Changes, and Clinical Relevance in Prostate Cancerges in the cancer-driven epigenetic process at the molecular level and correlates these alterations to nuclear morphological quantitative measurements. Finally, we address how we can best utilize this knowledge to improve the efficacy of personalized treatment of cancer.

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Nuclear Envelope: Connecting Structural Genome Organization to Regulation of Gene Expressionuclear periphery, and sequester transcription factors away from the nuclear interior. On the other hand, proteins of the nuclear pores anchor as well as help generate active chromatin, promote transcription, and coordinate gene expression with mRNA export. The importance of these functions is unders

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The Non-random Repositioning of Whole Chromosomes and Individual Gene Loci in Interphase Nuclei and nvelope defects can restore proper gene positioning and expression in both disease situations..Although spatial positioning of the genome probably does not entirely control expression of genes, it appears that spatio-epigenetics may enhance the control over gene expression globally and/or is deeply