Titlebook: Anticancer Drug Development Guide; Preclinical Screenin Beverly A. Teicher (Vice President and Director of Book 2004 Springer Science+Busin

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Human Tumor Xenograft Models in NCI Drug Developmentedition of this book .. In addition, a series of review articles have charted the evolution of the overall NCI drug discovery process, which began in 1955 .. Although the methodologies associated with xenograft model testing have remained fundamentally the same, during the past 10 yr a series of imp

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NCI Specialized Procedures in Preclinical Drug Evaluations, experimental agents have limited antiproliferative data against a broad spectrum of human cancers, and these agents usually are then tested in the NCI’ s in vitro anticancer drug screen. Data from the screen permits the identification of agents that exhibit differential activity among multiple tum

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Patient-Like Orthotopic Metastatic Models of Human Cancercancer to test and investigate the hypothesis of Paget as well as for treatment and drug discovery. Thus, there has been a critical need in cancer treatment and research for rodent models that are clinically relevant. Ideal models would allow the transplantation of the majority of human tumors such

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