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Titlebook: Anticancer Drug Development Guide; Preclinical Screenin Beverly A. Teicher (Vice President and Director of Book 2004 Springer Science+Busin

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發(fā)表于 2025-3-21 19:27:24 | 只看該作者 |倒序瀏覽 |閱讀模式
期刊全稱Anticancer Drug Development Guide
期刊簡稱Preclinical Screenin
影響因子2023Beverly A. Teicher (Vice President and Director of
視頻videohttp://file.papertrans.cn/159/158487/158487.mp4
發(fā)行地址Includes supplementary material:
學科分類Cancer Drug Discovery and Development
圖書封面Titlebook: Anticancer Drug Development Guide; Preclinical Screenin Beverly A. Teicher (Vice President and Director of Book 2004 Springer Science+Busin
影響因子This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute‘s high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earlies
Pindex Book 2004
The information of publication is updating

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Spontaneously Occurring Tumors in Companion Animals as Models for Drug Development (i.e., dog and cat pet population). Companion animals with naturally occurring tumors, although presently underutilized, have and should continue to provide an excellent opportunity to investigate many aspects of malignancy from etiology to treatment.
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https://doi.org/10.1007/978-3-540-34049-2 brief history of the in vivo screens used by the NCI, (2) a description of the human tumor xenograft systems that are employed in preclinical drug development, and (3) a discussion of how these xenograft models are employed for both initial efficacy testing as well as detailed drug evaluations.
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Human Tumor Xenograft Models in NCI Drug Development brief history of the in vivo screens used by the NCI, (2) a description of the human tumor xenograft systems that are employed in preclinical drug development, and (3) a discussion of how these xenograft models are employed for both initial efficacy testing as well as detailed drug evaluations.
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