Titlebook: Anticancer Drug Development Guide; Preclinical Screenin Beverly A. Teicher (Vice President and Director of Book 2004 Springer Science+Busin

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Patient-Like Orthotopic Metastatic Models of Human Cancerpt foreign tissues for human tumor transplantation. The modern era is characterized by new orthotopic transplant methodologies that allow human tumors to express their metastatic potential, especially the models developed in our laboratory that are constructed by surgical orthotopic implantation wit

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Models for Biomarkers and Minimal Residual Tumorhypothesis that a few viable malignant cells with proliferative capacity remain after therapy and eventually repopulate the primary tumor and/or grow into metastatic lesions. These minimal residual tumor cells exist at levels below detectability by standard techniques. Dendritic cell (DC)-based canc

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Nonclinical Testingts outweigh the potential risks to the patient. From a business perspective, with efficiency being the key to survival, success is most often measured by the company’s ability to reach its destination in the most expeditious manner while using the fewest resources and without compromising the qualit

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Nonclinical Testing for Oncology Drug ProductsELs) do not have to be defined, and only minimal nonclinical proof-of-concept studies need to be provided. Nonetheless, the difficulty and importance of providing a relevant nonclinical safety assessment program is greatly increased because the first patients treated with a new oncology drug are mos

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Book 2004ty against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earlies

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Lino Schmid,Thomas Holleczek,Gerhard Tr?ster important role in drug evaluation, but with the development of a large number of cytotoxic drugs, animal models are too costly and the delay is too long for these models to be used for large-scale screening.