Overview: This volume is the outcome of the International School of Phar- macology course sponsored as a NATO Advanced Study Institute and held in Erice (Sicily) at the Ettore Majorana Centre for Scientific Culture from October 3 through 12, 1980. The course, which consisted of lectures and teaching seminars, examined issues of international importance in all phases of drug development, assessment, and regu- lation. In order to recreate both the atmosphere and substance of the meeting, a variety of materials are included here: the papers pre- sented by the lecturers, a selection of key items f
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