Titlebook: Viruses and Apoptosis; Covadonga Alonso Book 2004 Springer-Verlag Berlin Heidelberg 2004 HIV.Herpes Virus.Viruses.apoptosis.cell.cell cycl

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Signal Transduction and Apoptosis Pathways as Therapeutic Targets,ast three decades, the design of antitumoral agents has been primarily based on the fact that tumor cells exhibit a higher proliferation rate than “normal” cells. As a consequence, drugs that are cytotoxic either by affecting DNA replication, cellular morphological integrity, or cellular metabolism,

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Book 2004th, elimination of the virus or latent infection.Viruses deliver genomes and p- teins with signaling potential into target cells, resulting in growth, prolife- tion and apoptosis.Viral infection modi?es key cell regulatory elements involved in apoptotic pathways to successfully accomplish viral repl

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Poliovirus and Apoptosis,ms concerning PV: the occurrence, in rare cases, of poliomyelitis outbreaks due to oral-vaccine-derived PV strains (Nomoto and Arita 2002); and the development of a new neuro-muscular pathology, called the post-polio syndrome, in poliomyelitis survivors long after the acute disease (Dalakas 1995).

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Induction of Transformed Cell-Specific Apoptosis by the Adenovirus E4orf4 Protein,hese include alterations in the cytoskeleton leading to cell rounding, cell shrinkage and membrane blebbing; chromatin condensation; and DNA fragmentation. At the final stages, the cell fragments into apoptotic bodies that are engulfed by neighboring cells.

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Cell Death Suppressors Encoded by Cytomegalovirus,. A number of viruses evolved with elaborate, often several, strategies to prevent or delay apoptotic host responses (O’Brien 1998; Tschopp et al. 1998). In this article I will review the current status of our knowledge on the cell-death suppressing strategies employed by cytomegaloviruses, a subset of 3-herpesviruses.

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,Manipulation of Apoptosis by Herpes Viruses (Kaposi’s Sarcoma Pathogenesis), in all forms of KS tumors, suggesting that KSHV is the etiology agent for the development of KS (Sarid et al. 1999). In addition to KS, KSHV also associates with primary effusion lymphoma (PEL) and an immunoblast variant of Castleman’s disease (CD), which are of B cell origin (Cesarman et al. 1995; Soulier et al. 1995).

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