Titlebook: Viral Heart Disease; Heinz-Dietrich Bolte Conference proceedings 1984 Springer-Verlag Berlin Heidelberg 1984 Antigen.Heart.Herzkrankheit.V

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Histopathological Aspects of Myocarditis with Special Reference to Mumps, Cytomegalovirus Infection arteries”, which may or may not be associated with inflammation elsewhere in the body” [21]. This definition is probably agreeable to most. For practical purposes, however, it is often difficult to establish morphologically whether or not certain structural changes are of an inflammatory (infectiou

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Relations Between Viral Infection of the Myocardium and the Synthesis of Collagen Types I and IIIuctural protein of the connective tissue in fibrotic areas is collagen. To get more information about the relationship between viral infection and the interstitial fibrosis, we studied the distribution of viral capsid and interstitial collagen types I and III using an experimental model of acute myo

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Animal Models of Congestive Heart Failure and Congestive (Dilated) Cardiomyopathy Due to Viral Myocation and cardiomyopathy has been suggest [1, 9–12], but complete evidence is still lacking. After studies on experimental coxsackievirus myocarditis [11, 13, 14], we found severe myocarditis in several inbred strains of mice inoculated with the M variant of encephalomyocarditis (EMC) virus [15–18].

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The Role of Virus-, and Immune-Mediated Cardiocyte Injury in Coxsackievirus B3-Induced Myocarditismost any virus has been associated with causing this disease, but RNA viruses, especially of the Picornavirus family, appear to predominate [22]. Among the picornaviruses, coxsackieviruses and echoviruses are the most important in clinical myocarditis. Coxsackieviruses are small (28–30 n.), nonbuddi

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Characterization of the Inflammatory Infiltrate in Human Myocarditis — An Endomyocardial Biopsy Stud murine Coxsackievirus myocarditis model as reviewed by Woodruff (1980) and as presented in this volume by Huber, have not been confirmed in the human disease. In addition, the animal studies reported to date have described certain immunologic events in peripheral blood or spleen cells and have not

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The Role of Eosinophils in Myocarditisscribed, and it has been suggested that eosinophils themselves may be involved in tissue injury leading to chronic heart disease [6]. It has also been suggested that tropical endomyocardial disease, in which a peripheral blood eosinophilia is less marked, may also be due to a toxic effect of eosinop

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Coxsackie B Virus-Specific IgM Responses in Patients with Cardiac and Other Diseaseshat Coxsackie B virus antigens have been detected in the endocardium of patients with valvular heart disease [3]. However, viruses are seldom isolated from patients with Coxsackie B virus-induced heart disease. Furthermore, significant rises in antibody titre are only occasionally detected [4, 5], p

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Cardiocytolysis by Sera of Patients Suffering from Acute Perimyocarditis% -20% of patients. Alcoholic cardiomyopathy or other microbial infections excluded, viral aetiology has to be considered in most cases, especially in the light of published epidemiological evidence for viral infections (Burch and Giles 1950). It was one purpose of this study to determine whether ch