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Titlebook: Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies; Yunchen Bi Book 2018 Springer-Verlag GmbH

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發(fā)表于 2025-3-21 17:17:16 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
編輯Yunchen Bi
視頻videohttp://file.papertrans.cn/882/881072/881072.mp4
概述Nominated as a distinguished doctoral dissertation by the Chinese Academy of Sciences.Studies the calcium regulation mechanism of T cell receptor (TCR) activation by combining biophysical (mainly nucl
叢書名稱Springer Theses
圖書封面Titlebook: Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies; Yunchen Bi Book 2018 Springer-Verlag GmbH
描述.This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included..
出版日期Book 2018
關(guān)鍵詞Calcium regulation; Dengue virus; NMR; Nanodisc technology; Nuclear magnetic resonance; Protein-lipid int
版次1
doihttps://doi.org/10.1007/978-3-662-54618-5
isbn_softcover978-3-662-57206-1
isbn_ebook978-3-662-54618-5Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer-Verlag GmbH Germany 2018
The information of publication is updating

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發(fā)表于 2025-3-21 21:57:27 | 只看該作者
Yunchen BiNominated as a distinguished doctoral dissertation by the Chinese Academy of Sciences.Studies the calcium regulation mechanism of T cell receptor (TCR) activation by combining biophysical (mainly nucl
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發(fā)表于 2025-3-22 01:49:00 | 只看該作者
Springer Theseshttp://image.papertrans.cn/t/image/881072.jpg
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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies978-3-662-54618-5Series ISSN 2190-5053 Series E-ISSN 2190-5061
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Yunchen Bih by itself most or all af the aims of wise policy. And we know that the impetus for a ban does not issue from a proven public injury but from a well-intentioned legalism whose full consequences probably were not foreseen. Finally, we know that the public has spoken against a ban not just patiently
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發(fā)表于 2025-3-23 05:02:44 | 只看該作者
Yunchen Bind governments are held accountable for policies; (b) an internal dimension in moral and ethical analysis in which individuals take into account the consequences of their actions and the criteria which bear upon their choices; and (c) a comprehensive dimension in social and cultural analysis in whic
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發(fā)表于 2025-3-23 07:06:03 | 只看該作者
h by itself most or all af the aims of wise policy. And we know that the impetus for a ban does not issue from a proven public injury but from a well-intentioned legalism whose full consequences probably were not foreseen. Finally, we know that the public has spoken against a ban not just patiently
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