Titlebook: Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells; Xiaoyang Zhao Book 2014 Springer Science+Business Medi

Inferior

Introduction,ng that mankind had achieved a huge breakthrough in somatic cell reprogramming and stem cell research. Recently, with the emergence of new reprogramming strategies, induced pluripotent stem (iPS) cells further promoted the development of these two research fields. In this section, some latest advanc

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Establishment of ESC Lines Derived from Mice, Rats, and Primate,is the most widely used experiment model, it is important to generate the gene knockout animal model in BN rat for biology research. Gene modification in the ESCs is a common way to generate transgenic animal models. As a result, we established the ESC line from BN rat to facilitate the generation o

進(jìn)步

Establishment of Highly Efficient Somatic Cell Reprogramming System to Generate iPSC Lines,for personalized regenerative medicine. However, the low induction efficiency and the potential safety problem were two obstacles for clinical application. This study focuses on how to enhance the induction efficiency and has found that knockout serum replacement (KOSR) could increase the induction

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深淵

Provenance

Conclusion,s is still challenging. In this dissertation, I focused on the generation of fully reprogrammed iPS cells, the quality control of iPSC induction, and the standards to assess the quality of iPS cells. In addition, I want to apply the findings in mice to the primate pluripotent stem cells to facilitat

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Pluripotency of iPSC and the Underlining Mechanism,e embryonic fibroblasts (MEF), neonatal tail tip fibroblasts (TTF), and produced iPS mouse by tetraploid complementation, demonstrating that iPSCs have the same developmental potential in vivo as the embryonic stem cells and can develop into various tissues and organs. This builds a solid foundation for the clinical application of iPSCs.

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Xiaoyang Zhaos resilient wurden die Kinder und Jugendlichen bezeichnet, die Krisen und Belastungen erfolgreich überwinden (s. auch Gartland et al. 2011) und sich trotz dysfunktionaler Familienverh?ltnisse, Scheidung, psychischer oder somatischer Erkrankungen der Eltern oder erfahrener Gewalt gesund entwickeln. D

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https://doi.org/10.1007/978-94-017-8819-9Dlk1-Dio3 region; embryonic stem cells; induced pluripotent stem cells; pluripotency; tetraploid complem