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Titlebook: Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells; Xiaoyang Zhao Book 2014 Springer Science+Business Medi

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發(fā)表于 2025-3-21 18:09:04 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
編輯Xiaoyang Zhao
視頻videohttp://file.papertrans.cn/881/880957/880957.mp4
概述Nominated as an outstanding Ph.D. thesis by Chinese Academy of Sciences, China.Covering methods to derive embryonic stem cells from various species.Designing an efficient system to generate induced pl
叢書(shū)名稱Springer Theses
圖書(shū)封面Titlebook: Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells; Xiaoyang Zhao Book 2014 Springer Science+Business Medi
描述Stem cells have the ability to differentiate into all types of cells within the body, thus have great therapeutic potential for regenerative medicine to treat complicated disorders, like Parkinson’s disease and spinal cord injury. There will also be many applications in drug development. However, several roadblocks, such as safety issues and low efficiency of pluripotent stem cell (PSC) line derivation need to be resolved before their clinical application. This thesis focuses on these two areas, so as to find methods to overcome the limitation. It covers deriving embryonic stem cells (ESCs) from several different species and reports an efficient system to generate induced pluripotent stem cells (iPSCs), and the first iPSC mice in the world. The results in this thesis confirm that somatic cells can be fully reprogrammed with the four Yamanaka factors. In addition, we have found that the Dlk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.
出版日期Book 2014
關(guān)鍵詞Dlk1-Dio3 region; embryonic stem cells; induced pluripotent stem cells; pluripotency; tetraploid complem
版次1
doihttps://doi.org/10.1007/978-94-017-8819-9
isbn_softcover978-94-024-0226-1
isbn_ebook978-94-017-8819-9Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer Science+Business Media Dordrecht 2014
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-21 20:19:34 | 只看該作者
Xiaoyang Zhaoiche in Bezug auf Werte, Verhalten usw. verst?rkt an ihren Peers orientieren. Andererseits wird die Zeit der Adoleszenz von vielen Eltern als eine spannungsreiche und oft belastende Zeit beschrieben, da Jugendliche vermehrt die Regeln der Familie infrage stellen und ihre Eigenst?ndigkeit und Unabh?n
板凳
發(fā)表于 2025-3-22 03:03:45 | 只看該作者
Book 2014lk1-Dio3 region can be a potential molecular marker to distinguish the fully reprogrammed iPSCs from partially reprogrammed ones. All of these results will help improve the safety of PSCs in the clinical applications and increase the current low induction efficiency of their production.
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發(fā)表于 2025-3-22 05:57:29 | 只看該作者
Studies of Pluripotency in Embryonic Stem Cells and Induced Pluripotent Stem Cells
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發(fā)表于 2025-3-23 03:12:50 | 只看該作者
Establishment of ESC Lines Derived from Mice, Rats, and Primate,f gene knockout animal. There were large differences in ESC morphology and self-renewal regulatory signaling pathways between human and mouse ESCs. Hence, in this chapter, we also compared the processes to establish ESC lines from the embryo of human and mice respectively.
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發(fā)表于 2025-3-23 07:46:46 | 只看該作者
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