Titlebook: Resistance to Tyrosine Kinase Inhibitors; Daniele Focosi Book 2016 Springer International Publishing Switzerland 2016 Cancer Cells.Inhibit

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978-3-319-83438-2Springer International Publishing Switzerland 2016

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Resistance to Tyrosine Kinase Inhibitors978-3-319-46091-8Series ISSN 2196-5501 Series E-ISSN 2196-551X

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Innocence

Indications for Tyrosine Kinase Inhibitors in the Treatment of Solid Tumors,nical trials showed survival benefit, setting new treatment indications. Moreover, new molecules are being developed targeting resistance mechanisms such as acquired mutations or feedback mechanisms of the upregulated signaling pathway. The available TKIs and their indications of use through clinical trials are listed and discussed.