Titlebook: Resistance to Tyrosine Kinase Inhibitors; Daniele Focosi Book 2016 Springer International Publishing Switzerland 2016 Cancer Cells.Inhibit

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2196-5501 to common denominators of small-molecule and antibody-derive.The volume will serve as a primer on tyrosine kinase signaling and its importance in cancer. The volume will first introduce the common denominators of small-molecule and antibody-derived inhibitors, as well as the general phenomenon of re

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Tyrosine Kinase Signaling Pathways in Normal and Cancer Cells,rcinogenesis. In this chapter, we will discuss signaling pathways engaging PTKs and their implications in the initiation and progression of several human malignancies. We will point out the principal cancer cell types known to be candidates for tyrosine kinases inhibitors (TKIs)-or monoclonal antibodies-based targeted therapies.

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Resistance to Tyrosine Kinase Inhibitors in Different Types of Solid Cancer,ould facilitate the identification of actionable targets and development of new combination therapies for cancer patients. Although extensive studies have been applied to elucidate the underlying mechanisms, evidence is far from enough to establish a well-defined picture to correct resistance. The u

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