| 書(shū)目名稱 | Quantification of Circulating Proteins | | 副標(biāo)題 | Theory and applicati | | 編輯 | Wim Th. Hermens,George M. Willems,Marja P. Visser | | 視頻video | http://file.papertrans.cn/781/780733/780733.mp4 | | 圖書(shū)封面 |  | | 描述 | Less than 50 years ago it was discovered that steady-state protein concentrations in plasma are the net result of continuous elimination and synthesis of protein molecules. The first quanti- tative studies on the turnover and distribution of plasma pro- teins were made around 1950, after the introduction of radio- labeled protein preparations. Around 1970, another development in quantitative interpre- tation of circulating proteins was initiated in clinical enzy- mology. Estimation of cumulative release into plasma of cellular enzymes can be helpful in a variety of diseases to assess the extent of tissue damage and to evaluate therapy. Enzymes can be considered as biological tracers, i.e. minute quantities of protein can be accurately determined by their spe- cific catalytic activities. However, radioactive tracers permit direct estimates of turnover and distr ibution by measurement of excreted radioactivity, possibilities that are not available for enzymes. Consequently, only a few techniques used in tracer studies with radiolabeled proteins can be applied to circulating tissue enzymes and this may explain the lack of communication between the fields of plasma protein metabolism a | | 出版日期 | Book 1982 | | 關(guān)鍵詞 | assessment; behavior; blood; cell death; complication; complications; enzymes; metabolism; molecule; plasma; p | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-009-7660-3 | | isbn_softcover | 978-94-009-7662-7 | | isbn_ebook | 978-94-009-7660-3 | | copyright | Martinus Nijhoff Publishers, The Hague 1982 |
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