Titlebook: Notch Signaling in Embryology and Cancer; J?rg Reichrath,Sandra Reichrath Book 20121st edition The Editor(s) (if applicable) and The Autho

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NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex,tain NPCs, whereas loss-of-function mutations in the critical components of the pathway cause precocious neuronal differentiation and NPC depletion. Hairy and Enhancer of split (Hes)-type transcription factors have long been thought to be the only Notch effectors for the maintenance of NPCs. Recentl

conquer

Notch Signaling and Development of the Hematopoietic System,ve hematopoiesis within specialized domains of hemogenic endothelium in the fetal dorsal aorta. In contrast, Notch is dispensable for the subsequent maintenance of hematopoietic stem cells in the adult bone marrow. Notch is a key regulator of early T-cell development in the thymus. An expanding numb

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The Role of Notch Signaling in Kidney Development and Disease,position and pH balance. The functional unit of this filter is the nephron, whose segmented architecture has been largely conserved in form and function throughout eukaryotic evolution. Not surprisingly, the core developmental pathways that regulate the formation of the nephron have also been conser

Extricate

Notch Signaling and the Developing Skeleton, of somite segmentation, patterning and differentiation into sclerotome pre-chondrogenic cells to allow for appropriate axial skeleton development. In addition, studies performed in vitro and in vivo demonstrate that Notch signaling suppresses chondrogenic and osteoblastic differentiation and negati

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Notch Signaling and the Developing Skin Epidermis, barrier that keeps the inside of the body moist and protects the body from outside assaults by physical, environmental and biological factors. The epidermis is maintained throughout life through the proliferation of stem cells and differentiation of their progeny. Notch signaling pathway is a highl

Constitution

Notch Signaling and the Developing Hair Follicle,mbers of the pathway. These studies revealed that whereas embryonic development of the hair follicle can be achieved without Notch, its postnatal development requires an intact Notch signaling in the hair bulb and the outer root sheath. Among the many roles played by Notch in the hair follicle, two

改進

Notch Signaling and the Developing Inner Ear, inner ear. Notch signaling has been considered to conduct the formation of this mosaic pattern through one of its famous functions, known as ‘lateral inhibition’. The two Notch ligands Delta-like1 and Jagged2 are believed to act synergistically at the stage of cell diversification in mammals. In ad

IRK

Notch Signaling Pathway and Cancer Metastasis,tastasis is composed of a series of successive incidents, mainly including epithelial-mesenchymal transition (EMT), malignant cell migration, resistance to anoikis, and angiogenesis and lymphangiogenesis processes. However, the complicated cellular and molecular mechanisms underlying and modulating

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Notch, Apoptosis and Cancer,sis. Perturbation in any of these processes invariably contributes to the development of cancer. In particular, defects in apoptosis are seen in virtually all types of human cancers. The Notch pathway plays an important role in cell fate determination in both embryonic development and organ homeosta