Titlebook: Notch Signaling in Embryology and Cancer; J?rg Reichrath,Sandra Reichrath Book 20121st edition The Editor(s) (if applicable) and The Autho

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Notch Signaling and the Developing Inner Ear,coalesce to form cochleovestibular ganglion. Notch signaling pathway is thought to function during the delamination through its lateral inhibitory mechanism. Recently, many experiments examining Notch-related gene expression patterns and direct functional analyses of genes have revealed multiple imp

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Notch Signaling Pathway and Cancer Metastasis,s chapter highlights the current evidence for aberration of the Notch signaling in metastasis of tumors such as osteosarcoma, breast cancer, prostate cancer, and melanoma. In these studies, Notch activity seems to participate in cancer metastasis by modulating the EMT, tumor angiogenesis processes,

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The Molecular Basis of Notch Signaling: A Brief Overview, and adult tissue homeostasis. Notably, both abnormal increases and deficiencies of Notch signaling result in human developmental anomalies and cancer development implying that the precise regulation of the intensity and duration of Notch signals is imperative. Numerous studies have demonstrated tha

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The Role of Adams in Notch Signaling,smembrane region and then released into the cytoplasm to act as signaling molecules. In most if not all cases intramembrane cleavage is preceded and regulated by a membrane proximal cleavage step called ‘ectodomain shedding’. Here we will review the role of ectodomain shedding in RIP of the NOTCH si

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Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the ,-Fucosylation Of Nor domain of Notch contains a tandem array of epidermal growth factor-like (EGF-like) repeats. Some of these EGF-like repeats are .-fucosylated by protein .-fucosyltransferase 1 (.-fut1), which is essential for Notch signaling in . and mouse. This .-fucose is further modified by Fringe, a GlcNAc tran

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