| 書目名稱 | Nitrates Updated | | 副標(biāo)題 | Current Use in Angin | | 編輯 | Udho Thadani (Professor of Medicine, Vice Chief Ca | | 視頻video | http://file.papertrans.cn/667/666624/666624.mp4 | | 圖書封面 |  | | 描述 | Nitrates remain among the most commonly used therapeutic agents in cardiology. That they can re- lieve pain in angina pectoris has been known at least since 1867, when Lauder Brunton described their clinical use. Now, almost 130 years later, we are constantly learning more about their optimal use in anginal syndromes. For example, there is no doubt that nitrate tolerance occurs, but equally no doubt that certain drug dosages help to attenuate such toler- ance. Thus, our understanding of nitrate tolerance has been taken further by the advent of new nitrate preparations and by studies at a basic science level. The current intense interest in nitrates has been rekindled by the growing emphasis on the role of the endothelium in the production of nitric oxide, a basic cardiovascular regulator. If nitric oxide is vasodilator and protects the vascular endothelium, then nitrates should also have similar properties. Hence this book starts off with the role of the endothelium and ni- trates in vasodilation. Next, the mechanisms of ac- tion of nitrates are considered with emphasis on the role of cyclic GMP. The chief limitation to the use of nitrates lies in nitrate tolerance. After carefully | | 出版日期 | Book 1997 | | 關(guān)鍵詞 | angina pectoris; cardiovascular; drugs; heart; heart disease; heart failure; myocardial infarction | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4613-1135-5 | | isbn_softcover | 978-1-4612-8434-5 | | isbn_ebook | 978-1-4613-1135-5 | | copyright | Kluwer Academic Publishers 1997 |
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