Titlebook: Nitrates Updated; Current Use in Angin Udho Thadani (Professor of Medicine, Vice Chief Ca Book 1997 Kluwer Academic Publishers 1997 angina

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Clinical Pharmacokinetics of Nitrates,esent in plasma. The pharmacokinetics of isosorbide dinitrate are somewhat easier to understand. The substance disappears less rapidly from the plasma than does glyceryl trinitrate. After oral administration, there is also a hepatic first-pass extraction; the plasma concentrations can be prolonged b

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Short and Long-Acting Oral Nitrates for Stable Angina Pectoris,with the development of partial tolerance and appears to provide antianginal prophylaxis for only a period of 6 hours each day. Asymmetric bid therapy with ISDN at 7 a.m. and noon may give sustained effect but is supported by only a single, small study that did not examine effectiveness after the no

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Nitrates for Unstable Angina,arin, or both. Both aspirin and intravenous (IV) heparin or their combination reduce early mortality and the incidence of acute myocardial infarction in patients hospitalized with unstable angina. However, these agents do not promptly relieve chest pain. There are no placebo-controlled studies evalu

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Nitrates in Myocardial Infarction, Recent studies suggest that more prolonged therapy with nitrates spanning the healing phase of acute anterior Q-wave MI can further limit LV remodeling and preserve function. Results of the recently completed ISIS-4 and GISSI-3 megatrials suggest, however, that long-term nitrate in patients with su

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