Titlebook: Melanoma; David E. Fisher,Boris C. Bastian Reference work 2019 Springer Science+Business Media, LLC, part of Springer Nature 2019 melanoma

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Microbiome and Melanomaisease as well as in the adjuvant setting. We are gaining an appreciation of the factors that drive response and resistance to these therapies, and there is novel evidence that the microbiome (which refers to the microbes that inhabit our bodies along with their collective genomes) may shape overall

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Primary Cutaneous Melanocytic Neoplasmsed, congenital, and blue nevi. The predominant initiating genomic event in common acquired nevi is a mutation in BRAF, while a significantly smaller percentage have a mutation in NRAS. Mutations in NRAS occur far more frequently in congenital nevi; the ratio of NRAS to BRAF mutations in congenital n

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Inherited Contributions to Melanoma Riskand/or genetic loci mediating risk. A review of this progress, including rare high-penetrance gene mutations involved in familial melanoma as well as more common population variants of intermediate to low effect, is summarized in this chapter.

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clude recent breakthroughs in molecular diagnostics, breakthMelanoma is a cutting edge, comprehensive reference work on the topic of melanoma. The overarching goal is to provide detailed scholarly information which broadly covers all aspects of the clinical presentation and management of the disease

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Molecular Genetics of Melanocytic Neoplasiaanisms that transform melanocytes into benign melanocytic neoplasms and eventually melanomas. Thus, critical aspects of melanoma pathogenesis may be inferred from patterns of genetic alteration recurrent across subtypes of melanoma and melanocytic neoplasms.