Titlebook: Managing BRCA Mutation Carriers; Anees B. Chagpar Book 2017 Springer International Publishing AG 2017 Pathology of BCRA.DNA damage repair.

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Cristina O’Donoghue,Sonia Orcutt,Tuya Pal,Christine Laronga

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Genetic Evaluation for Women at Increased Risk, includes intake, risk assessment, pretest counseling and informed consent, and result disclosure and interpretation. Though the focus of this volume is the management of individuals with . mutations, any current discussion of hereditary breast and ovarian cancer would not be complete without mentio

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Imaging Screening and Surveillance, psychological consequences. There is no role for screening with any imaging modality in asymptomatic women who have undergone risk-reducing mastectomy. For . mutation carriers who have not undergone risk-reducing salpingo-oophorectomy by the recommended age, there is no evidence to date that ovaria

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Prophylactic Oophorectomy for Patients with Germline , Mutations, The procedure can be performed laparoscopically and can be combined with a hysterectomy in some patients including women with Lynch syndrome and those who will take tamoxifen or hormone replacement therapy following their rrBSO. However, despite the tremendous benefits derived from rrBSO in this pa

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ALE

amplitude

Fertility Preservation in , Carriers: Special Considerations,g. This should be considered for both previvors (patients who are .?+?but have not developed disease) and .?+?survivors (patients who have developed disease in the setting of a hereditary predisposition). While male . carriers are at increased risk of developing malignancies, most present later in l

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helper-T-cells