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Titlebook: Mammary Tumorigenesis and Malignant Progression; Advances in Cellular Robert B. Dickson,Marc E. Lippman Book 1994 Springer Science+Business

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發(fā)表于 2025-3-21 16:33:08 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書(shū)目名稱Mammary Tumorigenesis and Malignant Progression
副標(biāo)題Advances in Cellular
編輯Robert B. Dickson,Marc E. Lippman
視頻videohttp://file.papertrans.cn/623/622054/622054.mp4
叢書(shū)名稱Cancer Treatment and Research
圖書(shū)封面Titlebook: Mammary Tumorigenesis and Malignant Progression; Advances in Cellular Robert B. Dickson,Marc E. Lippman Book 1994 Springer Science+Business
描述The current volume represents the fourth over a period of five years in our series on Advances in the Cellular and Molecular Biology of Breast Cancer. The first three volumes were entitled Breast Cancer: Cellular and Molecular Biology, Regulatory Mechanisms in Breast Cancer, and Genes, Oncogenes, and Hormones, respectively. Throughout this series, we have tried to take a broad look at cutting-edge topics in basic science research into breast cancer. This attempt has resulted in a wide range of subject material, including rodent and human model systems, oncogenes, suppressor genes, growth factors, hormones, tumor-host interactions, and determinants of metastases. Since our last volume, research in breast cancer has continued to proceed at an explosive rate. We hope the current volume will provide the reader with some of the excitement felt by the editors and authors as we begin to understand this all-too-common disease. The first section of this book is devoted to the basic processes of proli- feration, differentiation, and malignant progression of breast cancer. T.l. Anderson and W.R. Miller lead off with a detailed description of controls on proliferation in the normal human breas
出版日期Book 1994
關(guān)鍵詞angiogenesis; biology; carcinogenesis; carcinoma; genes; hormones; metastasis; molecular biology; oncogene; o
版次1
doihttps://doi.org/10.1007/978-1-4615-2592-9
isbn_softcover978-1-4613-6109-1
isbn_ebook978-1-4615-2592-9Series ISSN 0927-3042 Series E-ISSN 2509-8497
issn_series 0927-3042
copyrightSpringer Science+Business Media New York 1994
The information of publication is updating

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Genetic analysis of breast and ovarian cancer in families.] and of ovarian cancer [.] can be attributed to inheritance of a gene conferring high risk, followed by genetic changes specific to the target epithelial cells of the breast or ovary. Given its very high incidence, breast cancer may also appear more than once in a family purely by bad luck, not be
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Tumor-suppressor genes in breast cancer progressionreast cancer, modifications of this model are necessary to account for differences in malignant progression between colon and breast cancers. Unlike colon cancer, there is much evidence suggesting that breast cancer is many different diseases. Supporting this hypothesis are the observations that mol
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Estrogen receptor variants in breast cancerreported that patients with inoperable breast tumors frequently responded to surgical castration [.], still a first-line therapeutic modality in premenopausal patients. Other manipulations designed to lower the concentrations of circulating E2 or to block its effects are also as effective, inducing
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The epidermal growth factor family in the mammary gland and other target organs for ovarian steroidsthe research investigator, and has emphasized the need to understand the pathways by which these compounds exert their effects on target organs. The clinical significance of the ovaries to breast cancer was evident around the turn of the century, when ovariectomy was shown to ameliorate the course o
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Molecular and clinical aspects of the Neu/ErbB-2 receptor tyrosine kinase,.]. Tumor development in humans is thought to reflect the multiplicity of events in the accumulation of independent mutations that affect clonal growth of the cancerous cell [.]. The identity of the group of genes that confer malignancy in vitro appears to be similar to the set of genes that are mu
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