Titlebook: Lynch Syndrome; Molecular Mechanism Naohiro Tomita Book 2020 Springer Nature Singapore Pte Ltd. 2020 Colorectal cancer.Colorectal neoplasm

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Surveillance Colonoscopy for Lynch Syndrome Affected Individuals,ex gastric cancer, and duodenal cancer, and also to surveillance of the relatives who have the same pathogenic variant of Lynch syndrome proband. In this paper, we introduce recent guidelines and reports from multicenter study in addition to an outline of the risk of gastrointestinal cancer in individuals with Lynch syndrome.

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Clinical Features of Lynch Syndrome,gastric cancer. The risk of developing LS-associated tumors may vary greatly depending on the population, gender of the carrier, and mismatch repair gene mutated. In this chapter, we discuss the clinical features of LS.

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Lynch Syndrome-Associated Urological Malignancies,, highlighting the importance of medical and family history of UTUC patients. Several studies have suggested that Lynch patients may have an increased risk of development of bladder and prostate cancer; however, this potential association may need further investigations because of the high incidence of those cancers in general population.

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Immunotherapy for Lynch Syndrome Patients,nction of antitumor T lymphocytes, the treatment of such dMMR-associated recurrent/metastatic cancers has drastically changed. This chapter aims to review some of the many advances in immunotherapy for Lynch syndrome patients with advanced cancers.

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Immunohistochemistry for Mismatch Repair Proteins,cognized for a correct evaluation to be made. This chapter discusses the backgrounds and practical issues regarding the use of immunohistochemistry for MMR proteins in the screening process for Lynch syndrome.

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Genetic Analysis for Lynch Syndrome,ssay. Although it is still difficult to detect some complex variants such as large insertion, inversion, complex rearrangement, and so on, these technologies will give more chances to diagnose with Lynch syndrome.

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Screening for Lynch Syndrome,proteins is similar to that of microsatellite instability; however, immunohistochemistry is more readily available and helps to direct gene testing. The universal genetic testing is reported from some groups; however, it is still premature to generalize the universal genetic testing as a screening test for Lynch syndrome.

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