Titlebook: Lynch Syndrome; Molecular Mechanism Naohiro Tomita Book 2020 Springer Nature Singapore Pte Ltd. 2020 Colorectal cancer.Colorectal neoplasm

摘要記錄

Jacket

Chemoprevention for Lynch Syndrome-Associated Malignancies,associated CRC yielded promising results for future clinical use. In this chapter, we introduce cancer chemoprevention and focus on the current status and future prospects of chemoprevention for LS-associated malignancies.

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BROW

Clinical Features of Lynch Syndrome, than 100,000 individuals in Japan carry LS variants. This autosomal dominant disease is mainly caused by germline variants of mismatch repair genes (., ., ., .) or .. Individuals with LS tend to develop with various types of tumors at a young age, such as colorectal cancer, endometrial cancer, and

CAMEO

Pathology of Lynch Syndrome-Associated Tumors,ined by immunohistochemistry, and loss of the proteins can be recognized visually, the carcinoma lesions arising in Lynch syndrome have some characteristic histological features in hematoxylin-eosin (H&E) staining. Most of the Lynch syndrome carcinomas are Microsatellite Instability-High (MSI-High),

vitrectomy

心神不寧

Fecundity

腐爛

Lynch Syndrome-Associated Urological Malignancies,n increased risk of development of upper tract urothelial carcinomas (UTUC) in Lynch syndrome and in fact, upper tract urothelial carcinoma has been found to be the third most common Lynch-associated malignancy. Interestingly, universal screening of UTUC exhibited that 5% of UTUC is Lynch-associated