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Titlebook: Lymphocytes, Macrophages, and Cancer; Georges Mathé,Irène Florentin,Marie-Christine Simm Book 1976 Springer-Verlag Berlin · Heidelberg 197

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發(fā)表于 2025-3-21 19:16:46 | 只看該作者 |倒序?yàn)g覽 |閱讀模式
書目名稱Lymphocytes, Macrophages, and Cancer
編輯Georges Mathé,Irène Florentin,Marie-Christine Simm
視頻videohttp://file.papertrans.cn/590/589212/589212.mp4
叢書名稱Recent Results in Cancer Research
圖書封面Titlebook: Lymphocytes, Macrophages, and Cancer;  Georges Mathé,Irène Florentin,Marie-Christine Simm Book 1976 Springer-Verlag Berlin · Heidelberg 197
描述Fresh living Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them highly cytotoxic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irrespective of the dose of BCG injected. The inhibitory effect was shown to be mediated by suppressor cells which had characteristics of macrophages since they could be removed by carbonyl iron and magnet treatment and were adherent to plastic. In contrast to it was observed after injec- tion of 1 mg of BCG, these suppressor cells alone did not account for the depression of T-cell re.sponses induced by higher doses of BCG. Nylon-nonadherent cell populations obtained from spleen cells treated with 3 or 5 mg BCG partially retained the inhibitory activity suggesting that suppressor T cells were also induced after injection of high doses of BCG. In contrast, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen ce
出版日期Book 1976
關(guān)鍵詞cancer; cell; lymphocytes; macrophages; neoplasm; tumor
版次1
doihttps://doi.org/10.1007/978-3-642-81049-7
isbn_softcover978-3-642-81051-0
isbn_ebook978-3-642-81049-7Series ISSN 0080-0015 Series E-ISSN 2197-6767
issn_series 0080-0015
copyrightSpringer-Verlag Berlin · Heidelberg 1976
The information of publication is updating

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Liposomes as Immunological Adjuvants,es and then on helper T-lymphocytes; for these the term T-adjuvants has been proposed. However, some adjuvants, such as bacterial lipopolysaccharide, appear to be able to stimulate B-lymphocytes directly without the agency of T-lympho-cytes; these can be termed B-adjuvants.
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Book 1976xic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irres
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In vitro Interactions Between Tumor Cells and Immune Lymphoid Cells,s it is useful to return to clear experimental models to try to etablish the significance of the in vitro methods used in investigations on cell-mediated antitumor immunity, and to determine whether the anti-tumor immune response is actually a response against the tumor or in fact an intercurrent phenomenon.
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An Immunological Classification of Leukemias and Hematosarcomas Based on Cell Membrane Markers withThe identification, several years ago, of membrane markers on the mononuclear cell population of both animals (.) and humans (., ., ., ., ., ., ., .) has permitted differentiation of this population into T- (thymodependent) and B- (thymoindependent) lymphocytes and a third cell category including monocytes (., .).
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,Increase in “Null” Cells in Acute Lymphocytic Leukemia in Remission on Long-Term Immunotherapy,these publications have recently appeared (., .). Although experimental evidence regarding the mechanism of action of BCG and/or inactivated tumor cells on animal immune systems is abundant (., ., ., ., .), consistent data in humans is still scanty.
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