Titlebook: Lipoxygenases and their Metabolites; Biological Functions Santosh Nigam,Cecil R. Pace-Asciak Book 1999 The Editor(s) (if applicable) and Th

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Adenosine,ble agonists. We report that endogenous adenosine (Ado) present in human PMN suspensions suppresses LTB. biosynthesis induced by platelet-activating factor (PAF). The blockade of the effects of Ado with an antagonist, theophylline, during the incubation of PMN resulted in significant enhancement of

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Pharmacological Aspects of 5-Lipoxygenase Inhibition,flammatory LTB., as well as the cysteinyl-leukotrienes LTC., LTD. and LTE.. Anti-leukotriene therapy may include direct (LOI—lipoxygenase inhibitors) or indirect (LSI—leukotriene synthesis inhibitors) inhibitors of 5-lipoxygenase, receptor antagonists to LTB. blocking the BLT receptor, and CysLT. re

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The Hepoxilins,ical actions of the hepoxilins and some of their chemical analogs. Some unpublished data are also presented. The primary biological action of the hepoxilins appears to relate to their ability to release calcium from intracellular stores through a receptor-mediated action. The receptor is intracellul

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Aspirin-Triggered 15-Epi-Lipoxin A4 and Stable Analogs of Lipoxin A4 are Potent Inhibitors of Acute surfaces by leukocyte-epithelial cell interactions. During these cell-cell interactions, transcellular biosynthetic pathways are used as major routes, and thus, in humans, LX are formed . during multicellular responses such as inflammation, atherosclerosis, and thrombosis (as reviewed in reference

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Receptors for Cysteinyl-Leukotrienes in Human Cells,loned so far. Recently, the classification and nomenclature of LT receptors has been proposed by an . committee appointed by the International Union of Pharmacology (IUPHAR), and has been officially approved by the latter (Coleman .., 1995; TiPS supplement, 1996). According to this nomenclature (Fig

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A 12(,)-Hete Receptor in Lewis Lung Carcinoma Cells,by several kinds of cells and tissues, e.g. platelets, macrophages, smooth muscle cells, tumor cells, keratinocytes, and by brain tissue (2). It is the major arachidonic acid metabolite in platelets but the precise biological function of this compound in platelets is unknown. It has been suggested t