Titlebook: Lipoprotein Metabolism and Atherogenesis; Toru Kita (Professor),Masayuki Yokode (Assistant P Conference proceedings 2000 Springer-Verlag T

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Molecular Genetics and Clinical Features of Japanese Patients with Familial Hypercholesterolemiain B (FDB) were never found in Japanese FH patients. Clinical features of FH, including responses to drugs, are partially dependent on LDL-receptor genotype. For the treatment of coronary heart disease in FH heterozygotes, LDL-apheresis is effective, and may become the therapy of choice in severe type of FH.

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Molecular mechanism of visceral obesity of multiple risk factors. Visceral fat is located upstream of the liver via the portal vein. Numerous free fatty acids released from visceral fat are drained into the liver and enhance expression of the genes for lipoprotein synthesis, leading to hyperlipemia. Visceral fat expresses numerous genes

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