| 書目名稱 | Lentiviral Vectors and Gene Therapy | | 編輯 | David Escors,Karine Breckpot,Holly Stephenson | | 視頻video | http://file.papertrans.cn/585/584970/584970.mp4 | | 概述 | Concise overview of the development of lentivectors and gene therapy, integrating historical facts, the development and experimental application of lentivectors.Ideal introduction and book of referenc | | 叢書名稱 | SpringerBriefs in Biochemistry and Molecular Biology | | 圖書封面 |  | | 描述 | .Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. .This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors | | 出版日期 | Book 2012 | | 關(guān)鍵詞 | cancer; clinical trial; gene therapy; lentivector; promoter; viral immunology; genetic engineering | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-0348-0402-8 | | isbn_softcover | 978-3-0348-0401-1 | | isbn_ebook | 978-3-0348-0402-8Series ISSN 2211-9353 Series E-ISSN 2211-9361 | | issn_series | 2211-9353 | | copyright | The Author(s) 2012 |
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