Titlebook: Kinesins and Cancer; Frank Kozielski, FSB Book 2015 Springer Science+Business Media Dordrecht 2015 Cancer chemotherapy.Human mitotic kines

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The Kinesin-6 Members MKLP1, MKLP2 and MPP1,bers have been characterised primarily because of their role in cell division, where they contribute to the regulation of the cytokinetic machinery as cells exit mitosis. Here we discuss the mechanisms by which MKLP1, MKLP2 and MPP1 regulate events during cell division and in post-mitotic tissues, h

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Non-motor Spindle Proteins as Cancer Chemotherapy Targets,ion. Both motor and non-motor microtubule associated proteins (MAPs) promote the assembly and disassembly of spindle microtubules during mitosis. Non-motor proteins localize to distinct subcellular sites, such as kinetochores and centrosomes, during different phases of mitosis. They are responsible

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Mechanisms of Action of Eg5 Inhibitors,ral mechanisms by which allosteric Eg5 inhibitors inhibit motor activity. I suggest that current Eg5 inhibitors work predominantly by stabilising the active site Mg. ion, and that they do this by stabilising the loop L5 in an apo-like conformation.

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Chromokinesins in Genome Maintenance and Cancer,apter we review the current knowledge of the structure, function and potential role of chromokinesins in cancer as well as the promise of this class of kinesins as candidate targets for therapeutic strategies.

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The Human Kinesin-14 Motor KifC1/HSET Is an Attractive Anti-cancer Drug Target,vations raise the tantalizing possibility that targeting HSET might be a promising cancer-selective chemotherapeutic approach. In this chapter, we summarize the multiple cellular roles played by HSET in various model systems and enumerate the steps required to validate and develop HSET as an anti-cancer drug target.