Titlebook: Kinesins and Cancer; Frank Kozielski, FSB Book 2015 Springer Science+Business Media Dordrecht 2015 Cancer chemotherapy.Human mitotic kines

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Kinesin-13 Microtubule Depolymerizing Proteins as Targets for Cancer Therapy,rly effective targets for drug development. This chapter reviews the activities of kinesin-13 proteins in the context of how they might be manipulated to affect spindle structure and advance cancer treatment by direct targeting, by enhancing the effectiveness of other current treatments, or by reversing resistance to other treatments.

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evance of kinesins to cancer treatment.Contributes to potent.This interdisciplinary volume collates research work on kinesins and cancer. Authors attempt to validate members of the kinesin superfamily as potential targets for drug development in cancer chemotherapy. The work begins by highlighting t

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Kif15: A Useful Target for Anti-cancer Therapy?, to the central player in mediating Eg5-independent bipolar spindle assembly. In this chapter, we describe the function of Kif15 during mitosis and discuss if Kif15 could be a target for drug development in anticancer therapy.

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Kinesin-8 Members and Their Potential as Biomarker or Therapeutic Target, the increased abundance may reflect a higher percentage of proliferative cells. Reduction of Kinesin-8 delays cells in mitosis and perturbs microtubule dynamics. Inhibitors of Kinesin-8 may therefore influence the proliferative capacity or may impair the migratory potential of cancer cells. These ideas remain to be tested.

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Clinical Trials of Mitotic Kinesin Inhibitors,nd less toxic inhibitors of the mitotic process. In this chapter, I review the clinical experience with one group of inhibitors that target mitotic kinesins. I will discuss the results of phase I and II trials with these drugs and place the results of these trials in a context to explain how they can be utilized in future human studies.

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978-94-024-0365-7Springer Science+Business Media Dordrecht 2015