Titlebook: Inotropic Stimulation and Myocardial Energetics; Hj. Just,Ch. Holubarsch,H. Scholz Conference proceedings 1989 Springer-Verlag Berlin Heid

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Myofibrillar Ca+ + activation and heart failure — Ca+ + sensitization by the cardiotonic agent APP 2n I phosphorylation. Interference of cardiotonic drugs with myofibrillar Ca. activation instead of enhancement of Ca. influx may therefore provide a more causal therapeutic concept in the treatment of cardiac insufficiency. APP 201–533 (3-Amino6-methyl-5-phenyl-2(1H)-pyridinone) (the structure of wh

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Do human cardiac beta-2 adrenoceptors play a (patho)physiological role in regulation of heart rate aating heart rate and/or contractility, however, is still an open question. Under normal physiological conditions cardiac ..-adrenoceptors may not be of functional importance, since heart rate and contractility seem to be under the control of noradrenaline that in the human heart acts nearly exclusiv

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Influence of isoproterenol on myocardial energetics. Experimental and clinical investigationseft ventricular function..The in vitro experiments were performed by simultaneous isometric force and heat measurements using sensitive antimony-bismuth thermopiles. Following the application of isoproterenol (10. M) isometric peak twitch tension and tension-time integral increased significantly by

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