Titlebook: Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors; John Vane,Jack Botting,Regina Botting Book 1996 Kluwer Academic Pub

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,Overview — mechanisms of action of anti-inflammatory drugs,, cell migration, tissue breakdown and repair. This overview will concentrate on the actions of anti-inflammatory drugs, with special reference to the prostaglandin system. This system is activated by phospholipase A., which liberates arachidonic acid, the substrate for cyclooxygenase (COX or PGH. s

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The dilemma of two cyclooxygenases: identifying the roles of COX-1 and COX-2 in inflammation and apous interest shown in comparing COX-1 and COX-2 expression has led to the generalization that COX-1, which is found in most tissues of mammals, is involved in physiological regulation of homeostasis. COX-2, on the other hand, is involved in the inflammatory response and certain physiological phenome

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COX-2 expression and inhibition in human monocytes,nd peroxidase activities.. PGH. is further metabolized by other enzymes to various prostanoids (PGs, prostacyclin and thromboxane A.). Two isozymes of PGHS exist, referred to as PGHS-1 and PGHS-2 or COX-1 and COX-2.. COX-1 is a constitutive enzyme present in almost all cell types., and is the major

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