| 書目名稱 | Improved Non-Steroid Anti-Inflammatory Drugs: COX-2 Enzyme Inhibitors | | 編輯 | John Vane,Jack Botting,Regina Botting | | 視頻video | http://file.papertrans.cn/463/462741/462741.mp4 | | 圖書封面 |  | | 描述 | In 1971, Vane proposed that the mechanism of action of the aspirin-like drugs was through their inhibition of prostaglandin biosynthesis. Since then, there has been intense interest in the interaction between this diverse group of inhibitors and the enzyme known as cyclooxygenase (COX). It exists in two isoforms, COX-l and COX-2 (discovered some 5 years ago). Over the last two decades several new drugs have reached the market based on COX-l enzyme screens. Elucidation of the three-dimensional structure of COX-l has provided a new understanding for the actions of COX inhibitors. The constitutive isoform of COX, COX-l has clear physiological functions. Its activation leads, for instance, to the production of prostacyclin which when released by the endothelium is anti-thrombogenic and anti-atherosclerotic, and in the gastric mucosa is cyto- protective. COX-l also generates prostaglandins in the kidney, where they help to maintain blood flow and promote natriuresis. The inducible isoform, COX-2, was discovered through its activity being increased in a number of cells by pro- inflammatory stimuli. A year or so later, COX-2 was identified as a distinct isoform encoded by a different gene | | 出版日期 | Book 1996 | | 關(guān)鍵詞 | cardiovascular disease; inflammation; kidney; kinetics; pharmacokinetics; pharmacology; research; toxicity | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-010-9029-2 | | isbn_softcover | 978-94-010-9031-5 | | isbn_ebook | 978-94-010-9029-2 | | copyright | Kluwer Academic Publishers and William Harvey Press 1996 |
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