Titlebook: Immunobiology of Bacterial CpG-DNA; Hermann Wagner Book 2000 The Editor(s) (if applicable) and The Author(s), under exclusive license to S

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Signal Transduction Pathways Activated by CpG-DNA, post-transcriptional activities. How can the information contained in unmethylated CpG-motifs in bacterial DNA be translated into gene expression? One possibility is that CpG-DNA, like other common ligands, engages a specific cellular receptor that transduces the signal by signal transduction pathw

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Role of Type I Interferons in T Cell Activation Induced by CpG DNA,eration (. et al. 1997). By contrast, DNA from nonvertebrates, which is largely unmethylated, is strongly stimulatory for B cells (. et al. 1997); this applies to DNA from bacteria, insects, nematodes, yeasts and mollusks. For bacteria, insect and yeast DNA, selective methylation of CpG motifs aboli

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Hematopoietic Remodeling Triggered by CpG DNA,timulating metabolic, cytotoxic, or phagocytic activities. Because, at any given time, progenitors in different hematopoietic organs are exposed to different cytokines and growth factors, the adaptive demand induced by infection on cellular composition and status can be met.

FID

CpG DNA in Cancer Immunotherapy,xin. Much of the antitumor activity of Coley’s toxin is attributed to endotoxin (. and . 1994). However, it is curious to note that Coley’s original success was with an organism that does not produce endotoxin. Thus, additional bacterial components, such as bacterial DNA, may well have played a role

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Responses of Human B Cells to DNA and Phosphorothioate Oligodeoxynucleotides,e cytosines within CpG dinucleotides in vertebrate genomes are methylated, whereas those in microbes and synthetic ODNs are non-methylated (. 1986, 1987; . et al. 1994). After testing a battery of ODNs for their immunostimulatory activities, . and his colleagues found that the stimulatory activity o