| 書(shū)目名稱(chēng) | Hyperbranched Polydendrons | | 副標(biāo)題 | A New Macromolecular | | 編輯 | Fiona L. Hatton | | 視頻video | http://file.papertrans.cn/431/430612/430612.mp4 | | 概述 | Nominated as an outstanding PhD thesis by the University of Liverpool, UK.Describes the development of a new class of materials, hyperbranched polydendrons.Examines hyperbranched polydendrons that for | | 叢書(shū)名稱(chēng) | Springer Theses | | 圖書(shū)封面 |  | | 描述 | This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe. | | 出版日期 | Book 2015 | | 關(guān)鍵詞 | Atom transfer radical polymerization; Controlled radical polymerisation; Dendritic polymer hybrid; Drug | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-319-18753-2 | | isbn_softcover | 978-3-319-36979-2 | | isbn_ebook | 978-3-319-18753-2Series ISSN 2190-5053 Series E-ISSN 2190-5061 | | issn_series | 2190-5053 | | copyright | Springer International Publishing Switzerland 2015 |
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