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Titlebook: Hyperbranched Polydendrons; A New Macromolecular Fiona L. Hatton Book 2015 Springer International Publishing Switzerland 2015 Atom transfer

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發(fā)表于 2025-3-21 16:24:14 | 只看該作者 |倒序瀏覽 |閱讀模式
書目名稱Hyperbranched Polydendrons
副標題A New Macromolecular
編輯Fiona L. Hatton
視頻videohttp://file.papertrans.cn/431/430612/430612.mp4
概述Nominated as an outstanding PhD thesis by the University of Liverpool, UK.Describes the development of a new class of materials, hyperbranched polydendrons.Examines hyperbranched polydendrons that for
叢書名稱Springer Theses
圖書封面Titlebook: Hyperbranched Polydendrons; A New Macromolecular Fiona L. Hatton Book 2015 Springer International Publishing Switzerland 2015 Atom transfer
描述This thesis outlines the first synthesis of a new complex branched polymer architecture that aims to combine the benefits of dendrimers with the simplicity of conventional polymerisation. There is no other available literature on these remarkable materials, dubbed hyperbranched polydendrons, due to their novelty. The new materials were shown to have very high molecular weights (>1,000,000 g/mol), exceptional self-assembly and encapsulation behaviour and unparalleled functionalisation capabilities, and were studied pharmacologically to determine their potential as oral nanomedicine candidates. The detailed investigation of the chemical variables involved in synthesising hyperbranched polydendrons has shown that their self-assembly and pharmacological behaviour can be turned on and off and fine-tuned by altering the composition of the materials. The permeation of the self-assembled particles through model gut epithelium suggests the potential for oral dosing of drug loaded nanomedicines that result in circulating nanoparticles – a research goal that is currently being pursued by several groups around the globe.
出版日期Book 2015
關鍵詞Atom transfer radical polymerization; Controlled radical polymerisation; Dendritic polymer hybrid; Drug
版次1
doihttps://doi.org/10.1007/978-3-319-18753-2
isbn_softcover978-3-319-36979-2
isbn_ebook978-3-319-18753-2Series ISSN 2190-5053 Series E-ISSN 2190-5061
issn_series 2190-5053
copyrightSpringer International Publishing Switzerland 2015
The information of publication is updating

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沙發(fā)
發(fā)表于 2025-3-21 20:17:34 | 只看該作者
Hyperbranched Polydendrons978-3-319-18753-2Series ISSN 2190-5053 Series E-ISSN 2190-5061
板凳
發(fā)表于 2025-3-22 00:33:46 | 只看該作者
Mixing Dendron and PEG Initiators for the Polymerisation of Branched pHPMA and Formation of Stericaonditions, it was desirable to produce nanoparticles which were sterically stabilised rather than charge stabilised. Steric stabilisation can be achieved through the incorporation of a hydrophilic moiety to the nanoparticle—usually a hydrophilic polymer.
地板
發(fā)表于 2025-3-22 06:00:10 | 只看該作者
Introduction,The relevant background to the thesis is dicussed, including various polymeric architectures and their methods of preparation. The formation of nano objects from polymers is also discussed in the context of drug delivery applications, ending with an introduction to the current research project.
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發(fā)表于 2025-3-22 09:48:48 | 只看該作者
Synthesis and Characterisation of ,-polydendron Materials and Subsequent Nanoparticle Formation,The synthesis of high generation dendrimers continues to be a non-cost effective and difficult process, as previously discussed, although the possibility of producing larger materials whilst maintaining such high surface functionality as present in dendrimers is highly desirable.
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發(fā)表于 2025-3-22 15:31:29 | 只看該作者
Conclusions and Future Work,The results of each chapter are discussed here with a focus on the major findings. A discussion around possible further work is also presented.
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Fiona L. HattonNominated as an outstanding PhD thesis by the University of Liverpool, UK.Describes the development of a new class of materials, hyperbranched polydendrons.Examines hyperbranched polydendrons that for
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Springer Theseshttp://image.papertrans.cn/h/image/430612.jpg
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