Titlebook: Hydrophilic Matrix Tablets for Oral Controlled Release; Peter Timmins,Samuel R. Pygall,Colin D. Melia Book 2014 American Association of Ph

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Hydrophilic Matrix Dosage Forms: Definitions, General Attributes, and the Evolution of Clinical Utiom a technology used late in the life cycle of a commercialized product to one that is now able to be applied very early in the research of an innovative medicine and so better enable its clinical use, is discussed.

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Microenvironmental pH Control and Mixed Polymer Approaches to Optimise Drug Delivery with Hydrophilthe use of mixed polymer systems to mitigate pH dependency of drug release is described. The optimisation of mixtures of polymers with pH-dependent and pH-independent properties (e.g. hydration, swelling) can also offer pH-independent drug release.

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In Vitro Physical and Imaging Techniques to Evaluate Drug Release Mechanisms from Hydrophilic Matrihnology are increasingly providing pharmaceutical scientists with new opportunities to gain unrivalled information in many aspects of the behaviour of hydrophilic matrices and their related performance characteristics.

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Keshan-disease

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Design and Evaluation of Hydroxypropyl Methylcellulose Matrix Tablets for Oral Controlled Release: nderpin our design and understanding of these systems today. These studies established HPMC (hypromellose) as an important matrix polymer, and identified key variables in polymer substitution, particle size, polymer:drug ratio and drug solubility as major determinants of drug release. The influence

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An Industrial Perspective on Hydrophilic Matrix Tablets Based on Hyproxypropyl Methylcellulose (Hyp matrix tablets. It shows how critical polymer attributes such as viscosity grade, substitution, particle size and batch consistency are important variables in matrix performance. The chapter also shows how the choice of excipients, manufacturing process and process variables can also influence matr

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