Titlebook: Hydrophilic Matrix Tablets for Oral Controlled Release; Peter Timmins,Samuel R. Pygall,Colin D. Melia Book 2014 American Association of Ph

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AAPS Advances in the Pharmaceutical Sciences Serieshttp://image.papertrans.cn/h/image/430497.jpg

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https://doi.org/10.1007/978-1-4939-1519-4cellulose ethers; controlled release; drug delivery; excipient; hydrophilic; polymer systems

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Hydrophilic Matrix Tablets for Oral Controlled Release978-1-4939-1519-4Series ISSN 2210-7371 Series E-ISSN 2210-738X

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Physiologically Based Pharmacokinetic Modeling in the Development and Evaluation of Hydrophilic Maton data as an input for PBPK modeling is described and the development of an in vitro–in vivo correlation (IVIVC) is covered. Finally, the limitations of PBPK modeling applied to hydrophilic matrix tablets are indicated.

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Extrusion: An Enabling Technology for Controlled-Release Hydrophilic Matrix Systems,g step, to simultaneously deliver drug over an extended period, enhance equilibrium drug solubility, and prevent the dissolved drug from precipitating out of saturated solution in the simulated GIT fluids for periods as long as 8 h. Twin-screw extrusion is a versatile enabling technology that is inc

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